| Karlsruhe to Oestrich-Winkel | 70.82 mi (113.97 km) |
| Karlsruhe to Offenburg | 43.19 mi (69.50 km) |
| Karlsruhe to Oftersheim | 26.27 mi (42.28 km) |
| Karlsruhe to Ohrdruf | 162.86 mi (262.09 km) |
| Karlsruhe to Ohringen | 51.30 mi (82.56 km) |
| Karlsruhe to Olbernhau | 247.65 mi (398.55 km) |
| Karlsruhe to Olching | 144.33 mi (232.28 km) |
| Karlsruhe to Oldenburg | 285.80 mi (459.95 km) |
| Karlsruhe to Oldenburg in Holstein | 380.63 mi (612.57 km) |
| Karlsruhe to Olfen | 192.40 mi (309.64 km) |
| Karlsruhe to Olpe | 141.00 mi (226.92 km) |
| Karlsruhe to Olsberg | 161.77 mi (260.35 km) |
| Karlsruhe to Oranienburg | 333.53 mi (536.77 km) |
| Karlsruhe to Ortenberg | 97.49 mi (156.89 km) |
| Karlsruhe to Oschatz | 261.46 mi (420.79 km) |
