| Karlsruhe to Salzhemmendorf | 217.50 mi (350.03 km) |
| Karlsruhe to Salzkotten | 184.11 mi (296.30 km) |
| Karlsruhe to Salzwedel | 291.02 mi (468.35 km) |
| Karlsruhe to Sande | 310.89 mi (500.33 km) |
| Karlsruhe to Sandhausen | 25.82 mi (41.55 km) |
| Karlsruhe to Sangerhausen | 212.59 mi (342.13 km) |
| Karlsruhe to Sankt Augustin | 133.18 mi (214.33 km) |
| Karlsruhe to Sankt Georgen im Schwarzwald | 61.20 mi (98.50 km) |
| Karlsruhe to Sankt Ingbert | 61.54 mi (99.04 km) |
| Karlsruhe to Sankt Leon-Rot | 19.76 mi (31.80 km) |
| Karlsruhe to Sankt Wendel | 64.15 mi (103.23 km) |
| Karlsruhe to Sarstedt | 232.13 mi (373.57 km) |
| Karlsruhe to Sassenberg | 206.55 mi (332.41 km) |
| Karlsruhe to Sassenburg | 261.16 mi (420.30 km) |
| Karlsruhe to Sassnitz | 441.25 mi (710.12 km) |
