| Karlsruhe to Schwetzingen | 26.87 mi (43.25 km) |
| Karlsruhe to Schwieberdingen | 31.77 mi (51.14 km) |
| Karlsruhe to Sebnitz | 294.00 mi (473.15 km) |
| Karlsruhe to Seeheim-Jugenheim | 53.49 mi (86.09 km) |
| Karlsruhe to Seelze | 239.77 mi (385.87 km) |
| Karlsruhe to Seesen | 213.99 mi (344.38 km) |
| Karlsruhe to Seevetal | 310.32 mi (499.42 km) |
| Karlsruhe to Sehnde | 238.47 mi (383.78 km) |
| Karlsruhe to Selb | 185.17 mi (298.01 km) |
| Karlsruhe to Seligenstadt | 75.12 mi (120.90 km) |
| Karlsruhe to Selm | 189.17 mi (304.43 km) |
| Karlsruhe to Senden | 200.91 mi (323.33 km) |
| Karlsruhe to Senden | 89.70 mi (144.36 km) |
| Karlsruhe to Sendenhorst | 197.49 mi (317.83 km) |
| Karlsruhe to Senftenberg | 302.31 mi (486.52 km) |
