| Karlsruhe to Siegburg | 134.84 mi (217.00 km) |
| Karlsruhe to Siegen | 130.63 mi (210.22 km) |
| Karlsruhe to Sigmaringen | 73.78 mi (118.73 km) |
| Karlsruhe to Simbach am Inn | 216.73 mi (348.79 km) |
| Karlsruhe to Simmerath | 144.51 mi (232.56 km) |
| Karlsruhe to Sindelfingen | 34.04 mi (54.78 km) |
| Karlsruhe to Sinsheim | 27.32 mi (43.97 km) |
| Karlsruhe to Sinzheim | 20.20 mi (32.51 km) |
| Karlsruhe to Sinzig | 117.92 mi (189.78 km) |
| Karlsruhe to Soest | 177.49 mi (285.64 km) |
| Karlsruhe to Solingen | 160.15 mi (257.73 km) |
| Karlsruhe to Soltau | 281.51 mi (453.05 km) |
| Karlsruhe to Sommerda | 191.24 mi (307.77 km) |
| Karlsruhe to Sondershausen | 195.94 mi (315.33 km) |
| Karlsruhe to Sonneberg | 154.38 mi (248.45 km) |
