| Karlsruhe to Sonsbeck | 200.64 mi (322.90 km) |
| Karlsruhe to Sonthofen | 134.53 mi (216.51 km) |
| Karlsruhe to Spaichingen | 66.27 mi (106.66 km) |
| Karlsruhe to Spelle | 235.58 mi (379.12 km) |
| Karlsruhe to Spenge | 215.88 mi (347.43 km) |
| Karlsruhe to Speyer | 21.47 mi (34.55 km) |
| Karlsruhe to Spiesen-Elversberg | 61.22 mi (98.53 km) |
| Karlsruhe to Spremberg | 317.53 mi (511.01 km) |
| Karlsruhe to Springe | 227.23 mi (365.70 km) |
| Karlsruhe to Sprockhovel | 170.69 mi (274.71 km) |
| Karlsruhe to Stade | 320.60 mi (515.96 km) |
| Karlsruhe to Stadtallendorf | 128.95 mi (207.52 km) |
| Karlsruhe to Stadthagen | 231.76 mi (372.98 km) |
| Karlsruhe to Stadtlohn | 216.25 mi (348.02 km) |
| Karlsruhe to Stahnsdorf | 314.49 mi (506.13 km) |
