| Karlsruhe to Stockach | 84.70 mi (136.32 km) |
| Karlsruhe to Stockelsdorf | 350.33 mi (563.81 km) |
| Karlsruhe to Stolberg | 155.17 mi (249.73 km) |
| Karlsruhe to Stollberg | 227.42 mi (366.00 km) |
| Karlsruhe to Straelen | 193.28 mi (311.05 km) |
| Karlsruhe to Stralsund | 417.28 mi (671.54 km) |
| Karlsruhe to Straubing | 189.07 mi (304.28 km) |
| Karlsruhe to Strausberg | 343.68 mi (553.10 km) |
| Karlsruhe to Stuhr | 277.30 mi (446.27 km) |
| Karlsruhe to Stuttgart | 38.72 mi (62.31 km) |
| Karlsruhe to Sudlohn | 213.71 mi (343.93 km) |
| Karlsruhe to Suhl | 150.52 mi (242.23 km) |
| Karlsruhe to Sulingen | 253.30 mi (407.64 km) |
| Karlsruhe to Sulz am Neckar | 45.85 mi (73.79 km) |
| Karlsruhe to Sulzbach | 77.86 mi (125.30 km) |
