| Karlsruhe to Sala Consilina | 691.16 mi (1,112.31 km) |
| Karlsruhe to Salemi | 803.82 mi (1,293.63 km) |
| Karlsruhe to Salerno | 653.73 mi (1,052.07 km) |
| Karlsruhe to Salo | 255.78 mi (411.64 km) |
| Karlsruhe to Salsomaggiore Terme | 299.18 mi (481.48 km) |
| Karlsruhe to Saluzzo | 304.59 mi (490.18 km) |
| Karlsruhe to Salzano | 296.52 mi (477.21 km) |
| Karlsruhe to Samarate | 235.07 mi (378.31 km) |
| Karlsruhe to San Benedetto del Tronto | 494.15 mi (795.25 km) |
| Karlsruhe to San Biagio di Callalta | 295.50 mi (475.56 km) |
| Karlsruhe to San Bonifacio | 283.59 mi (456.40 km) |
| Karlsruhe to San Casciano in Val di Pesa | 392.83 mi (632.19 km) |
| Karlsruhe to San Cataldo | 843.82 mi (1,358.00 km) |
| Karlsruhe to San Cesareo | 540.53 mi (869.89 km) |
| Karlsruhe to San Dona di Piave | 304.02 mi (489.28 km) |
