| Karlsruhe to Santeramo in Colle | 698.51 mi (1,124.14 km) |
| Karlsruhe to Santo Stefano di Magra | 342.46 mi (551.13 km) |
| Karlsruhe to Santo Stino di Livenza | 302.11 mi (486.19 km) |
| Karlsruhe to Sarezzo | 246.85 mi (397.26 km) |
| Karlsruhe to Sarno | 641.99 mi (1,033.18 km) |
| Karlsruhe to Saronno | 235.66 mi (379.26 km) |
| Karlsruhe to Sarzana | 346.22 mi (557.18 km) |
| Karlsruhe to Sassari | 572.32 mi (921.05 km) |
| Karlsruhe to Sasso Marconi | 345.77 mi (556.47 km) |
| Karlsruhe to Sassuolo | 327.91 mi (527.71 km) |
| Karlsruhe to Sava | 744.68 mi (1,198.45 km) |
| Karlsruhe to Saviano | 633.48 mi (1,019.49 km) |
| Karlsruhe to Savigliano | 303.38 mi (488.25 km) |
| Karlsruhe to Savignano sul Panaro | 336.52 mi (541.58 km) |
| Karlsruhe to Savignano sul Rubicone | 389.15 mi (626.28 km) |
