| Karlsruhe to Smolyan | 940.67 mi (1,513.86 km) |
| Karlsruhe to Sofia | 838.01 mi (1,348.64 km) |
| Karlsruhe to Sopot | 898.63 mi (1,446.20 km) |
| Karlsruhe to Sozopol | 1,032.44 mi (1,661.55 km) |
| Karlsruhe to Sredets | 1,013.58 mi (1,631.20 km) |
| Karlsruhe to Stamboliyski | 910.62 mi (1,465.50 km) |
| Karlsruhe to Stara Zagora | 944.80 mi (1,520.52 km) |
| Karlsruhe to Svilengrad | 994.49 mi (1,600.48 km) |
| Karlsruhe to Svishtov | 887.86 mi (1,428.88 km) |
| Karlsruhe to Targovishte | 953.98 mi (1,535.28 km) |
| Karlsruhe to Teteven | 867.99 mi (1,396.90 km) |
| Karlsruhe to Troyan | 888.11 mi (1,429.27 km) |
| Karlsruhe to Tryavna | 921.74 mi (1,483.39 km) |
| Karlsruhe to Tutrakan | 928.19 mi (1,493.78 km) |
| Karlsruhe to Varna | 1,012.99 mi (1,630.24 km) |
