| Karlsruhe to Schijndel | 222.76 mi (358.49 km) |
| Karlsruhe to Schinnen | 174.69 mi (281.14 km) |
| Karlsruhe to Schoonhoven | 256.26 mi (412.41 km) |
| Karlsruhe to Simpelveld | 165.75 mi (266.75 km) |
| Karlsruhe to Sint Anthonis | 212.28 mi (341.63 km) |
| Karlsruhe to Sint Willebrord | 243.16 mi (391.33 km) |
| Karlsruhe to Sint-Michielsgestel | 226.16 mi (363.97 km) |
| Karlsruhe to Sint-Oedenrode | 219.12 mi (352.65 km) |
| Karlsruhe to Sittard | 177.79 mi (286.12 km) |
| Karlsruhe to Sliedrecht | 251.48 mi (404.72 km) |
| Karlsruhe to Slochteren | 298.90 mi (481.03 km) |
| Karlsruhe to Sluis | 272.98 mi (439.32 km) |
| Karlsruhe to Sneek | 302.43 mi (486.71 km) |
| Karlsruhe to Soest | 258.07 mi (415.33 km) |
| Karlsruhe to Someren | 202.54 mi (325.96 km) |
