| Karlsruhe to Skarzysko-Kamienna | 572.99 mi (922.13 km) |
| Karlsruhe to Skawina | 516.78 mi (831.67 km) |
| Karlsruhe to Skierniewice | 554.53 mi (892.43 km) |
| Karlsruhe to Skoczow | 469.68 mi (755.88 km) |
| Karlsruhe to Skwierzyna | 396.62 mi (638.30 km) |
| Karlsruhe to Slawno | 511.34 mi (822.92 km) |
| Karlsruhe to Slubice | 354.86 mi (571.09 km) |
| Karlsruhe to Slupca | 472.26 mi (760.02 km) |
| Karlsruhe to Slupsk | 526.86 mi (847.89 km) |
| Karlsruhe to Sochaczew | 563.52 mi (906.90 km) |
| Karlsruhe to Sokolka | 718.62 mi (1,156.52 km) |
| Karlsruhe to Sokolow Podlaski | 648.32 mi (1,043.36 km) |
| Karlsruhe to Solec Kujawski | 510.73 mi (821.94 km) |
| Karlsruhe to Sopot | 573.87 mi (923.56 km) |
| Karlsruhe to Sosnowiec | 487.56 mi (784.66 km) |
