| Karlsruhe to Setubal | 1,122.10 mi (1,805.85 km) |
| Karlsruhe to Sever do Vouga | 997.13 mi (1,604.72 km) |
| Karlsruhe to Silves | 1,173.69 mi (1,888.87 km) |
| Karlsruhe to Sines | 1,149.59 mi (1,850.08 km) |
| Karlsruhe to Sintra | 1,127.51 mi (1,814.55 km) |
| Karlsruhe to Sobrado de Paiva | 979.76 mi (1,576.77 km) |
| Karlsruhe to Sobral de Monte Agraco | 1,107.85 mi (1,782.92 km) |
| Karlsruhe to Soure | 1,038.87 mi (1,671.90 km) |
| Karlsruhe to Tabua | 1,000.85 mi (1,610.71 km) |
| Karlsruhe to Tavira | 1,149.51 mi (1,849.95 km) |
| Karlsruhe to Tomar | 1,051.64 mi (1,692.46 km) |
| Karlsruhe to Tondela | 995.76 mi (1,602.52 km) |
| Karlsruhe to Torre de Moncorvo | 927.31 mi (1,492.36 km) |
| Karlsruhe to Torres Novas | 1,062.50 mi (1,709.93 km) |
| Karlsruhe to Torres Vedras | 1,109.13 mi (1,784.98 km) |
