| Karlsruhe to Sangeorz-Bai | 756.71 mi (1,217.80 km) |
| Karlsruhe to Sannicolau Mare | 603.93 mi (971.94 km) |
| Karlsruhe to Santana | 635.38 mi (1,022.54 km) |
| Karlsruhe to Satu Mare | 668.79 mi (1,076.32 km) |
| Karlsruhe to Scobinti | 858.56 mi (1,381.72 km) |
| Karlsruhe to Scornicesti | 821.07 mi (1,321.38 km) |
| Karlsruhe to Sebes | 737.37 mi (1,186.68 km) |
| Karlsruhe to Seini | 687.34 mi (1,106.17 km) |
| Karlsruhe to Sfantu-Gheorghe | 838.90 mi (1,350.08 km) |
| Karlsruhe to Sibiu | 767.65 mi (1,235.41 km) |
| Karlsruhe to Sighetu Marmatiei | 712.20 mi (1,146.17 km) |
| Karlsruhe to Sighisoara | 785.57 mi (1,264.25 km) |
| Karlsruhe to Simeria | 715.42 mi (1,151.35 km) |
| Karlsruhe to Sinaia | 841.91 mi (1,354.93 km) |
| Karlsruhe to Slatina | 817.54 mi (1,315.70 km) |
