| Karlsruhe to Ruzomberok | 493.45 mi (794.12 km) |
| Karlsruhe to Sabinov | 573.55 mi (923.04 km) |
| Karlsruhe to Sal'a | 436.79 mi (702.95 km) |
| Karlsruhe to Samorin | 413.04 mi (664.72 km) |
| Karlsruhe to Senec | 414.28 mi (666.72 km) |
| Karlsruhe to Senica | 407.93 mi (656.50 km) |
| Karlsruhe to Sered' | 428.40 mi (689.44 km) |
| Karlsruhe to Skalica | 400.46 mi (644.48 km) |
| Karlsruhe to Smizany | 549.25 mi (883.93 km) |
| Karlsruhe to Snina | 622.56 mi (1,001.92 km) |
| Karlsruhe to Spisska Nova Ves | 551.05 mi (886.83 km) |
| Karlsruhe to Stara L'ubovna | 554.41 mi (892.23 km) |
| Karlsruhe to Stara Tura | 422.15 mi (679.39 km) |
| Karlsruhe to Stropkov | 598.59 mi (963.34 km) |
| Karlsruhe to Stupava | 396.93 mi (638.79 km) |
