| Karlsruhe to Santander | 696.78 mi (1,121.36 km) |
| Karlsruhe to Santany | 716.03 mi (1,152.35 km) |
| Karlsruhe to Santiago de Compostela | 915.08 mi (1,472.68 km) |
| Karlsruhe to Santiago del Teide | 1,956.71 mi (3,149.02 km) |
| Karlsruhe to Santiponce | 1,077.36 mi (1,733.84 km) |
| Karlsruhe to Santomera | 890.82 mi (1,433.64 km) |
| Karlsruhe to Santona | 683.95 mi (1,100.71 km) |
| Karlsruhe to Santurce-Antiguo | 672.15 mi (1,081.73 km) |
| Karlsruhe to Sarria | 871.50 mi (1,402.54 km) |
| Karlsruhe to Sauzal | 1,932.88 mi (3,110.66 km) |
| Karlsruhe to Sedavi | 791.11 mi (1,273.17 km) |
| Karlsruhe to Segorbe | 768.82 mi (1,237.30 km) |
| Karlsruhe to Segovia | 825.57 mi (1,328.63 km) |
| Karlsruhe to Senmanat | 594.69 mi (957.07 km) |
| Karlsruhe to Sesena | 854.50 mi (1,375.19 km) |
