| Key Largo to Atlanta (Georgia) | 643.74 mi (1,035.99 km) |
| Key Largo to Houston (Texas) | 972.17 mi (1,564.56 km) |
| Key Largo to Washington (District of Columbia) | 972.61 mi (1,565.26 km) |
| Key Largo to Baltimore (Maryland) | 1,004.48 mi (1,616.56 km) |
| Key Largo to Philadelphia (Pennsylvania) | 1,072.85 mi (1,726.59 km) |
| Key Largo to St. Louis (Missouri) | 1,095.92 mi (1,763.72 km) |
| Key Largo to Dallas (Texas) | 1,119.88 mi (1,802.27 km) |
| Key Largo to Brooklyn (New York) | 1,135.62 mi (1,827.60 km) |
| Key Largo to New York (New York) | 1,138.93 mi (1,832.94 km) |
| Key Largo to Queens (New York) | 1,144.93 mi (1,842.58 km) |
| Key Largo to Detroit (Michigan) | 1,202.42 mi (1,935.10 km) |
| Key Largo to Chicago (Illinois) | 1,227.43 mi (1,975.36 km) |
| Key Largo to Boston (Massachusetts) | 1,301.44 mi (2,094.47 km) |
| Key Largo to Minneapolis (Minnesota) | 1,547.35 mi (2,490.21 km) |
| Key Largo to Denver (Colorado) | 1,739.07 mi (2,798.76 km) |
| Key Largo to Phoenix (Arizona) | 1,986.17 mi (3,196.43 km) |
| Key Largo to Las Vegas (Nevada) | 2,194.48 mi (3,531.67 km) |
| Key Largo to San Diego (California) | 2,269.85 mi (3,652.96 km) |
| Key Largo to Riverside (California) | 2,291.73 mi (3,688.18 km) |
| Key Largo to Los Angeles (California) | 2,350.53 mi (3,782.82 km) |
| Key Largo to Tampa (Florida) | 234.85 mi (377.96 km) |
| Key Largo to San Francisco (California) | 2,602.07 mi (4,187.62 km) |
| Key Largo to Portland (Oregon) | 2,723.54 mi (4,383.11 km) |
| Key Largo to Seattle (Washington) | 2,753.14 mi (4,430.75 km) |
| Key Largo to Miami (Florida) | 47.42 mi (76.31 km) |
