| Key Largo to Sacile | 5,122.71 mi (8,244.20 km) |
| Key Largo to Sala Consilina | 5,409.37 mi (8,705.53 km) |
| Key Largo to Salemi | 5,339.34 mi (8,592.84 km) |
| Key Largo to Salerno | 5,361.18 mi (8,627.98 km) |
| Key Largo to Salo | 5,041.70 mi (8,113.84 km) |
| Key Largo to Salsomaggiore Terme | 5,033.58 mi (8,100.76 km) |
| Key Largo to Saluzzo | 4,920.91 mi (7,919.43 km) |
| Key Largo to Salzano | 5,115.51 mi (8,232.62 km) |
| Key Largo to Samarate | 4,960.99 mi (7,983.95 km) |
| Key Largo to San Benedetto del Tronto | 5,260.40 mi (8,465.80 km) |
| Key Largo to San Biagio di Callalta | 5,123.95 mi (8,246.19 km) |
| Key Largo to San Bonifacio | 5,080.55 mi (8,176.35 km) |
| Key Largo to San Casciano in Val di Pesa | 5,116.27 mi (8,233.84 km) |
| Key Largo to San Cataldo | 5,407.96 mi (8,703.28 km) |
| Key Largo to San Cesareo | 5,237.46 mi (8,428.87 km) |
