| Key Largo to Santa Ursula | 3,902.81 mi (6,280.97 km) |
| Key Largo to Santander | 4,395.99 mi (7,074.66 km) |
| Key Largo to Santany | 4,811.40 mi (7,743.20 km) |
| Key Largo to Santiago de Compostela | 4,166.74 mi (6,705.72 km) |
| Key Largo to Santiago del Teide | 3,885.64 mi (6,253.33 km) |
| Key Largo to Santiponce | 4,362.68 mi (7,021.05 km) |
| Key Largo to Santomera | 4,618.07 mi (7,432.07 km) |
| Key Largo to Santona | 4,413.39 mi (7,102.67 km) |
| Key Largo to Santurce-Antiguo | 4,435.85 mi (7,138.82 km) |
| Key Largo to Sarria | 4,224.23 mi (6,798.24 km) |
| Key Largo to Sauzal | 3,905.30 mi (6,284.97 km) |
| Key Largo to Sedavi | 4,629.17 mi (7,449.93 km) |
| Key Largo to Segorbe | 4,616.55 mi (7,429.62 km) |
| Key Largo to Segovia | 4,413.57 mi (7,102.96 km) |
| Key Largo to Senmanat | 4,719.18 mi (7,594.78 km) |
