| Key Largo to Shoreham-by-Sea | 4,471.49 mi (7,196.17 km) |
| Key Largo to Shotley Bridge | 4,367.81 mi (7,029.30 km) |
| Key Largo to Shrewsbury | 4,348.35 mi (6,997.99 km) |
| Key Largo to Sidcup | 4,480.85 mi (7,211.24 km) |
| Key Largo to Sidmouth | 4,344.79 mi (6,992.26 km) |
| Key Largo to Sileby | 4,416.56 mi (7,107.76 km) |
| Key Largo to Sittingbourne | 4,508.96 mi (7,256.47 km) |
| Key Largo to Skegness | 4,472.11 mi (7,197.17 km) |
| Key Largo to Skelmersdale | 4,340.92 mi (6,986.03 km) |
| Key Largo to Skipton | 4,368.58 mi (7,030.55 km) |
| Key Largo to Sleaford | 4,442.60 mi (7,149.67 km) |
| Key Largo to Slough | 4,450.61 mi (7,162.56 km) |
| Key Largo to Small Heath | 4,387.91 mi (7,061.66 km) |
| Key Largo to Smethwick | 4,382.87 mi (7,053.55 km) |
| Key Largo to Snaresbrook | 4,475.33 mi (7,202.34 km) |
