| Key Largo to Channelview (Texas) | 956.47 mi (1,539.30 km) |
| Key Largo to Chantilly (Virginia) | 966.62 mi (1,555.62 km) |
| Key Largo to Chaparral (New Mexico) | 1,643.28 mi (2,644.61 km) |
| Key Largo to Chapel Hill (North Carolina) | 750.96 mi (1,208.56 km) |
| Key Largo to Charleston (Illinois) | 1,089.91 mi (1,754.04 km) |
| Key Largo to Charleston (South Carolina) | 532.30 mi (856.66 km) |
| Key Largo to Charleston (West Virginia) | 916.61 mi (1,475.14 km) |
| Key Largo to Charlotte (North Carolina) | 697.31 mi (1,122.22 km) |
| Key Largo to Charlottesville (Virginia) | 899.46 mi (1,447.54 km) |
| Key Largo to Chaska (Minnesota) | 1,547.71 mi (2,490.80 km) |
| Key Largo to Chatham (Illinois) | 1,140.30 mi (1,835.13 km) |
| Key Largo to Chattanooga (Tennessee) | 745.09 mi (1,199.11 km) |
| Key Largo to Cheat Lake (West Virginia) | 1,005.45 mi (1,618.12 km) |
| Key Largo to Chelsea (Alabama) | 679.24 mi (1,093.14 km) |
| Key Largo to Chelsea (Massachusetts) | 1,307.41 mi (2,104.07 km) |
