| Key Largo to Colton (California) | 2,288.54 mi (3,683.05 km) |
| Key Largo to Columbia (Illinois) | 1,084.91 mi (1,745.99 km) |
| Key Largo to Columbia (Maryland) | 994.41 mi (1,600.34 km) |
| Key Largo to Columbia (Missouri) | 1,180.59 mi (1,899.97 km) |
| Key Largo to Columbia (Pennsylvania) | 1,054.97 mi (1,697.81 km) |
| Key Largo to Columbia (South Carolina) | 616.70 mi (992.48 km) |
| Key Largo to Columbia (Tennessee) | 825.85 mi (1,329.07 km) |
| Key Largo to Columbia Heights (Minnesota) | 1,551.80 mi (2,497.38 km) |
| Key Largo to Columbine (Colorado) | 1,742.55 mi (2,804.36 km) |
| Key Largo to Columbus (Georgia) | 577.41 mi (929.26 km) |
| Key Largo to Columbus (Indiana) | 1,024.64 mi (1,649.00 km) |
| Key Largo to Columbus (Mississippi) | 753.00 mi (1,211.83 km) |
| Key Largo to Columbus (Nebraska) | 1,487.11 mi (2,393.28 km) |
| Key Largo to Columbus (Ohio) | 1,037.73 mi (1,670.07 km) |
| Key Largo to Commack (New York) | 1,161.07 mi (1,868.56 km) |
