| Key Largo to Crawfordsville (Indiana) | 1,097.03 mi (1,765.50 km) |
| Key Largo to Crest Hill (Illinois) | 1,219.06 mi (1,961.89 km) |
| Key Largo to Crestview (Florida) | 540.85 mi (870.41 km) |
| Key Largo to Crestwood (Illinois) | 1,216.18 mi (1,957.26 km) |
| Key Largo to Crestwood (Missouri) | 1,095.53 mi (1,763.09 km) |
| Key Largo to Creve Coeur (Missouri) | 1,103.49 mi (1,775.89 km) |
| Key Largo to Crofton (Maryland) | 984.14 mi (1,583.82 km) |
| Key Largo to Crossville (Tennessee) | 796.86 mi (1,282.42 km) |
| Key Largo to Crowley (Louisiana) | 811.64 mi (1,306.21 km) |
| Key Largo to Crowley (Texas) | 1,145.65 mi (1,843.74 km) |
| Key Largo to Crown Point (Indiana) | 1,193.74 mi (1,921.14 km) |
| Key Largo to Crystal (Minnesota) | 1,554.08 mi (2,501.05 km) |
| Key Largo to Crystal Lake (Illinois) | 1,265.51 mi (2,036.65 km) |
| Key Largo to Cudahy (California) | 2,336.87 mi (3,760.83 km) |
| Key Largo to Cudahy (Wisconsin) | 1,301.99 mi (2,095.35 km) |
