| Key Largo to Des Plaines (Illinois) | 1,244.20 mi (2,002.34 km) |
| Key Largo to Desert Hot Springs (California) | 2,243.25 mi (3,610.16 km) |
| Key Largo to DeSoto (Texas) | 1,119.64 mi (1,801.88 km) |
| Key Largo to Destin (Florida) | 519.34 mi (835.79 km) |
| Key Largo to Destrehan (Louisiana) | 695.14 mi (1,118.73 km) |
| Key Largo to Detroit (Michigan) | 1,202.42 mi (1,935.10 km) |
| Key Largo to Diamond Bar (California) | 2,316.15 mi (3,727.48 km) |
| Key Largo to Diamond Springs (California) | 2,525.26 mi (4,064.02 km) |
| Key Largo to Dickinson (North Dakota) | 1,941.93 mi (3,125.23 km) |
| Key Largo to Dickinson (Texas) | 947.02 mi (1,524.09 km) |
| Key Largo to Dickson (Tennessee) | 861.08 mi (1,385.77 km) |
| Key Largo to Difficult Run (Virginia) | 968.66 mi (1,558.91 km) |
| Key Largo to Dinuba (California) | 2,424.85 mi (3,902.42 km) |
| Key Largo to Discovery Bay (California) | 2,557.68 mi (4,116.19 km) |
| Key Largo to Dix Hills (New York) | 1,157.41 mi (1,862.67 km) |
