| Key Largo to Duluth (Minnesota) | 1,629.33 mi (2,622.16 km) |
| Key Largo to Dumas (Texas) | 1,477.21 mi (2,377.34 km) |
| Key Largo to Dumont (New Jersey) | 1,153.87 mi (1,856.98 km) |
| Key Largo to Duncan (Oklahoma) | 1,231.99 mi (1,982.70 km) |
| Key Largo to Duncanville (Texas) | 1,123.56 mi (1,808.19 km) |
| Key Largo to Dundalk (Maryland) | 1,003.72 mi (1,615.33 km) |
| Key Largo to Dunedin (Florida) | 248.91 mi (400.57 km) |
| Key Largo to Dunkirk (New York) | 1,200.87 mi (1,932.62 km) |
| Key Largo to Dunmore (Pennsylvania) | 1,158.92 mi (1,865.10 km) |
| Key Largo to Dunwoody (Georgia) | 652.75 mi (1,050.49 km) |
| Key Largo to Durango (Colorado) | 1,817.87 mi (2,925.58 km) |
| Key Largo to Durant (Oklahoma) | 1,137.16 mi (1,830.09 km) |
| Key Largo to Durham (North Carolina) | 755.46 mi (1,215.79 km) |
| Key Largo to Dyer (Indiana) | 1,202.23 mi (1,934.80 km) |
| Key Largo to Dyersburg (Tennessee) | 923.13 mi (1,485.64 km) |
