| Key Largo to Friendly (Maryland) | 963.49 mi (1,550.60 km) |
| Key Largo to Friendswood (Texas) | 956.12 mi (1,538.72 km) |
| Key Largo to Frisco (Texas) | 1,133.17 mi (1,823.67 km) |
| Key Largo to Front Royal (Virginia) | 962.53 mi (1,549.05 km) |
| Key Largo to Fruit Cove (Florida) | 351.55 mi (565.77 km) |
| Key Largo to Fruita (Colorado) | 1,907.55 mi (3,069.91 km) |
| Key Largo to Fruitville (Florida) | 198.64 mi (319.68 km) |
| Key Largo to Fuller Heights (Florida) | 216.89 mi (349.06 km) |
| Key Largo to Fullerton (California) | 2,321.83 mi (3,736.62 km) |
| Key Largo to Fullerton (Pennsylvania) | 1,108.53 mi (1,784.00 km) |
| Key Largo to Fulshear (Texas) | 998.96 mi (1,607.67 km) |
| Key Largo to Fulton (Missouri) | 1,162.90 mi (1,871.51 km) |
| Key Largo to Fulton (New York) | 1,277.27 mi (2,055.57 km) |
| Key Largo to Fuquay-Varina (North Carolina) | 730.10 mi (1,174.98 km) |
| Key Largo to Gadsden (Alabama) | 699.93 mi (1,126.44 km) |
