| Key Largo to Isabela (Puerto Rico) | 972.37 mi (1,564.88 km) |
| Key Largo to Iselin (New Jersey) | 1,123.64 mi (1,808.32 km) |
| Key Largo to Isla Vista (California) | 2,435.01 mi (3,918.78 km) |
| Key Largo to Issaquah (Washington) | 2,739.18 mi (4,408.29 km) |
| Key Largo to Ithaca (New York) | 1,217.31 mi (1,959.08 km) |
| Key Largo to Ives Estates (Florida) | 59.82 mi (96.27 km) |
| Key Largo to Jackson (Michigan) | 1,204.60 mi (1,938.62 km) |
| Key Largo to Jackson (Mississippi) | 773.69 mi (1,245.13 km) |
| Key Largo to Jackson (Missouri) | 1,006.23 mi (1,619.38 km) |
| Key Largo to Jackson (Tennessee) | 883.15 mi (1,421.30 km) |
| Key Largo to Jackson (Wyoming) | 2,127.51 mi (3,423.89 km) |
| Key Largo to Jacksonville (Alabama) | 680.51 mi (1,095.17 km) |
| Key Largo to Jacksonville (Arkansas) | 971.30 mi (1,563.16 km) |
| Key Largo to Jacksonville (Florida) | 368.15 mi (592.47 km) |
| Key Largo to Jacksonville (Illinois) | 1,158.60 mi (1,864.59 km) |
