| Key Largo to Lowell (Indiana) | 1,187.29 mi (1,910.76 km) |
| Key Largo to Lowell (Massachusetts) | 1,315.85 mi (2,117.66 km) |
| Key Largo to Lower Burrell (Pennsylvania) | 1,068.90 mi (1,720.23 km) |
| Key Largo to Lowes Island (Virginia) | 978.46 mi (1,574.67 km) |
| Key Largo to Lubbock (Texas) | 1,415.16 mi (2,277.48 km) |
| Key Largo to Lufkin (Texas) | 969.93 mi (1,560.95 km) |
| Key Largo to Luling (Louisiana) | 692.44 mi (1,114.37 km) |
| Key Largo to Lumberton (North Carolina) | 662.25 mi (1,065.79 km) |
| Key Largo to Lumberton (Texas) | 914.61 mi (1,471.93 km) |
| Key Largo to Lutz (Florida) | 243.40 mi (391.72 km) |
| Key Largo to Lynbrook (New York) | 1,141.42 mi (1,836.93 km) |
| Key Largo to Lynchburg (Virginia) | 851.36 mi (1,370.13 km) |
| Key Largo to Lynden (Washington) | 2,790.11 mi (4,490.25 km) |
| Key Largo to Lyndhurst (Ohio) | 1,134.46 mi (1,825.74 km) |
| Key Largo to Lyndon (Kentucky) | 957.22 mi (1,540.49 km) |
