| Key Largo to Merrick (New York) | 1,143.39 mi (1,840.11 km) |
| Key Largo to Merrifield (Virginia) | 967.87 mi (1,557.64 km) |
| Key Largo to Merrillville (Indiana) | 1,197.00 mi (1,926.39 km) |
| Key Largo to Merritt Island (Florida) | 221.09 mi (355.81 km) |
| Key Largo to Mesa (Arizona) | 1,963.24 mi (3,159.53 km) |
| Key Largo to Mesquite (Nevada) | 2,140.74 mi (3,445.18 km) |
| Key Largo to Mesquite (Texas) | 1,109.38 mi (1,785.38 km) |
| Key Largo to Metairie (Louisiana) | 686.10 mi (1,104.17 km) |
| Key Largo to Methuen Town (Massachusetts) | 1,324.72 mi (2,131.93 km) |
| Key Largo to Metuchen (New Jersey) | 1,121.04 mi (1,804.15 km) |
| Key Largo to Mexico (Missouri) | 1,176.92 mi (1,894.06 km) |
| Key Largo to Miami (Florida) | 47.42 mi (76.31 km) |
| Key Largo to Miami (Oklahoma) | 1,177.98 mi (1,895.77 km) |
| Key Largo to Miami Beach (Florida) | 50.92 mi (81.94 km) |
| Key Largo to Miami Gardens (Florida) | 57.69 mi (92.85 km) |
