| Key Largo to Savannah (Georgia) | 479.45 mi (771.60 km) |
| Key Largo to Sayreville (New Jersey) | 1,116.77 mi (1,797.26 km) |
| Key Largo to Sayville (New York) | 1,159.11 mi (1,865.40 km) |
| Key Largo to Scaggsville (Maryland) | 990.14 mi (1,593.48 km) |
| Key Largo to Scarsdale (New York) | 1,160.78 mi (1,868.10 km) |
| Key Largo to Schaumburg (Illinois) | 1,247.58 mi (2,007.79 km) |
| Key Largo to Schenectady (New York) | 1,275.81 mi (2,053.22 km) |
| Key Largo to Schererville (Indiana) | 1,200.23 mi (1,931.59 km) |
| Key Largo to Schertz (Texas) | 1,135.82 mi (1,827.92 km) |
| Key Largo to Schiller Park (Illinois) | 1,238.73 mi (1,993.55 km) |
| Key Largo to Schofield Barracks (Hawaii) | 4,862.94 mi (7,826.15 km) |
| Key Largo to Scotchtown (New York) | 1,181.84 mi (1,901.98 km) |
| Key Largo to Scottdale (Georgia) | 642.29 mi (1,033.67 km) |
| Key Largo to Scotts Valley (California) | 2,572.69 mi (4,140.34 km) |
| Key Largo to Scottsbluff (Nebraska) | 1,759.54 mi (2,831.71 km) |
