| Key Largo to Security-Widefield (Colorado) | 1,699.27 mi (2,734.71 km) |
| Key Largo to Sedalia (Missouri) | 1,199.97 mi (1,931.16 km) |
| Key Largo to Sedro-Woolley (Washington) | 2,769.99 mi (4,457.87 km) |
| Key Largo to Seguin (Texas) | 1,119.33 mi (1,801.38 km) |
| Key Largo to Selden (New York) | 1,167.71 mi (1,879.26 km) |
| Key Largo to Selma (Alabama) | 643.72 mi (1,035.96 km) |
| Key Largo to Selma (California) | 2,436.95 mi (3,921.89 km) |
| Key Largo to Selma (Texas) | 1,139.63 mi (1,834.06 km) |
| Key Largo to Seminole (Florida) | 238.45 mi (383.75 km) |
| Key Largo to Seven Hills (Ohio) | 1,125.64 mi (1,811.54 km) |
| Key Largo to Seven Oaks (South Carolina) | 618.22 mi (994.93 km) |
| Key Largo to Severn (Maryland) | 992.07 mi (1,596.58 km) |
| Key Largo to Severna Park (Maryland) | 990.45 mi (1,593.98 km) |
| Key Largo to Sevierville (Tennessee) | 766.99 mi (1,234.36 km) |
| Key Largo to Seymour (Indiana) | 1,007.14 mi (1,620.84 km) |
