| Key Largo to Seymour (Tennessee) | 769.37 mi (1,238.19 km) |
| Key Largo to Shady Hills (Florida) | 262.21 mi (421.98 km) |
| Key Largo to Shafter (California) | 2,404.78 mi (3,870.13 km) |
| Key Largo to Shaker Heights (Ohio) | 1,131.69 mi (1,821.28 km) |
| Key Largo to Shakopee (Minnesota) | 1,541.78 mi (2,481.25 km) |
| Key Largo to Sharon (Pennsylvania) | 1,113.22 mi (1,791.55 km) |
| Key Largo to Sharonville (Ohio) | 1,005.56 mi (1,618.29 km) |
| Key Largo to Shasta Lake (California) | 2,630.26 mi (4,232.99 km) |
| Key Largo to Shawnee (Kansas) | 1,274.06 mi (2,050.41 km) |
| Key Largo to Shawnee (Oklahoma) | 1,212.01 mi (1,950.55 km) |
| Key Largo to Sheboygan (Wisconsin) | 1,350.91 mi (2,174.08 km) |
| Key Largo to Shelby (North Carolina) | 705.77 mi (1,135.83 km) |
| Key Largo to Shelbyville (Indiana) | 1,043.41 mi (1,679.21 km) |
| Key Largo to Shelbyville (Kentucky) | 946.98 mi (1,524.02 km) |
| Key Largo to Shelbyville (Tennessee) | 801.89 mi (1,290.52 km) |
