| Key Largo to Shoreview (Minnesota) | 1,551.05 mi (2,496.18 km) |
| Key Largo to Shorewood (Illinois) | 1,217.69 mi (1,959.69 km) |
| Key Largo to Shorewood (Wisconsin) | 1,311.71 mi (2,110.99 km) |
| Key Largo to Short Hills (New Jersey) | 1,134.43 mi (1,825.70 km) |
| Key Largo to Short Pump (Virginia) | 881.30 mi (1,418.31 km) |
| Key Largo to Show Low (Arizona) | 1,878.87 mi (3,023.75 km) |
| Key Largo to Shreveport (Louisiana) | 954.83 mi (1,536.65 km) |
| Key Largo to Sicklerville (New Jersey) | 1,058.02 mi (1,702.72 km) |
| Key Largo to Sidney (Ohio) | 1,070.12 mi (1,722.19 km) |
| Key Largo to Sierra Madre (California) | 2,330.58 mi (3,750.70 km) |
| Key Largo to Sierra Vista (Arizona) | 1,865.73 mi (3,002.60 km) |
| Key Largo to Sierra Vista Southeast (Arizona) | 1,859.10 mi (2,991.93 km) |
| Key Largo to Signal Hill (California) | 2,335.09 mi (3,757.97 km) |
| Key Largo to Sikeston (Missouri) | 976.48 mi (1,571.49 km) |
| Key Largo to Siloam Springs (Arkansas) | 1,132.72 mi (1,822.94 km) |
