| Key Largo to Smyrna (Delaware) | 1,018.17 mi (1,638.58 km) |
| Key Largo to Smyrna (Georgia) | 652.26 mi (1,049.71 km) |
| Key Largo to Smyrna (Tennessee) | 832.55 mi (1,339.87 km) |
| Key Largo to Snellville (Georgia) | 640.81 mi (1,031.28 km) |
| Key Largo to Snoqualmie (Washington) | 2,729.79 mi (4,393.18 km) |
| Key Largo to Snyder (Texas) | 1,343.11 mi (2,161.53 km) |
| Key Largo to Socastee (South Carolina) | 597.74 mi (961.97 km) |
| Key Largo to Socorro (Texas) | 1,630.03 mi (2,623.28 km) |
| Key Largo to Soddy-Daisy (Tennessee) | 755.50 mi (1,215.85 km) |
| Key Largo to Solana Beach (California) | 2,278.45 mi (3,666.81 km) |
| Key Largo to Soledad (California) | 2,531.15 mi (4,073.50 km) |
| Key Largo to Solon (Ohio) | 1,125.28 mi (1,810.97 km) |
| Key Largo to Somers Point (New Jersey) | 1,037.14 mi (1,669.12 km) |
| Key Largo to Somerset (Kentucky) | 862.67 mi (1,388.34 km) |
| Key Largo to Somerset (New Jersey) | 1,116.37 mi (1,796.63 km) |
