| Key Largo to South Plainfield (New Jersey) | 1,122.21 mi (1,806.03 km) |
| Key Largo to South Portland (Maine) | 1,400.47 mi (2,253.83 km) |
| Key Largo to South Riding (Virginia) | 967.63 mi (1,557.25 km) |
| Key Largo to South River (New Jersey) | 1,114.47 mi (1,793.57 km) |
| Key Largo to South Salt Lake (Utah) | 2,103.02 mi (3,384.49 km) |
| Key Largo to South San Francisco (California) | 2,599.83 mi (4,184.01 km) |
| Key Largo to South San Jose Hills (California) | 2,321.26 mi (3,735.71 km) |
| Key Largo to South Sioux City (Nebraska) | 1,504.21 mi (2,420.80 km) |
| Key Largo to South St. Paul (Minnesota) | 1,537.06 mi (2,473.66 km) |
| Key Largo to South Valley (New Mexico) | 1,706.14 mi (2,745.76 km) |
| Key Largo to South Venice (Florida) | 181.91 mi (292.75 km) |
| Key Largo to South Whittier (California) | 2,328.02 mi (3,746.59 km) |
| Key Largo to South Yarmouth (Massachusetts) | 1,283.82 mi (2,066.11 km) |
| Key Largo to Southaven (Mississippi) | 887.04 mi (1,427.55 km) |
| Key Largo to Southchase (Florida) | 232.98 mi (374.95 km) |
