| Key Largo to St. Simons (Georgia) | 422.54 mi (680.02 km) |
| Key Largo to Stafford (Texas) | 979.51 mi (1,576.37 km) |
| Key Largo to Stallings (North Carolina) | 690.15 mi (1,110.69 km) |
| Key Largo to Stamford (Connecticut) | 1,172.27 mi (1,886.58 km) |
| Key Largo to Stanford (California) | 2,584.19 mi (4,158.85 km) |
| Key Largo to Stanton (California) | 2,325.08 mi (3,741.86 km) |
| Key Largo to Star (Idaho) | 2,396.19 mi (3,856.30 km) |
| Key Largo to Starkville (Mississippi) | 766.96 mi (1,234.30 km) |
| Key Largo to State College (Pennsylvania) | 1,092.53 mi (1,758.27 km) |
| Key Largo to Staten Island (New York) | 1,127.58 mi (1,814.66 km) |
| Key Largo to Statesboro (Georgia) | 512.10 mi (824.15 km) |
| Key Largo to Statesville (North Carolina) | 737.16 mi (1,186.35 km) |
| Key Largo to Staunton (Virginia) | 904.23 mi (1,455.22 km) |
| Key Largo to Steamboat Springs (Colorado) | 1,853.22 mi (2,982.47 km) |
| Key Largo to Steiner Ranch (Texas) | 1,127.35 mi (1,814.29 km) |
