| Key Largo to Storm Lake (Iowa) | 1,473.12 mi (2,370.75 km) |
| Key Largo to Storrs (Connecticut) | 1,243.64 mi (2,001.45 km) |
| Key Largo to Stoughton (Wisconsin) | 1,327.52 mi (2,136.43 km) |
| Key Largo to Stow (Ohio) | 1,110.78 mi (1,787.63 km) |
| Key Largo to Streamwood (Illinois) | 1,248.85 mi (2,009.83 km) |
| Key Largo to Streator (Illinois) | 1,206.66 mi (1,941.94 km) |
| Key Largo to Streetsboro (Ohio) | 1,114.88 mi (1,794.22 km) |
| Key Largo to Strongsville (Ohio) | 1,121.61 mi (1,805.05 km) |
| Key Largo to Stuart (Florida) | 143.64 mi (231.17 km) |
| Key Largo to Stuarts Draft (Virginia) | 894.70 mi (1,439.88 km) |
| Key Largo to Sturgis (Michigan) | 1,187.25 mi (1,910.70 km) |
| Key Largo to Suamico (Wisconsin) | 1,414.72 mi (2,276.77 km) |
| Key Largo to Sudley (Virginia) | 959.38 mi (1,543.97 km) |
| Key Largo to Suffern (New York) | 1,162.09 mi (1,870.20 km) |
| Key Largo to Suffolk (Virginia) | 830.07 mi (1,335.88 km) |
