| Key West to Orangevale (California) | 2,493.60 mi (4,013.07 km) |
| Key West to Orchards (Washington) | 2,684.54 mi (4,320.35 km) |
| Key West to Orcutt (California) | 2,409.11 mi (3,877.09 km) |
| Key West to Oregon (Ohio) | 1,184.49 mi (1,906.25 km) |
| Key West to Oregon (Wisconsin) | 1,340.42 mi (2,157.20 km) |
| Key West to Oregon City (Oregon) | 2,679.72 mi (4,312.60 km) |
| Key West to Orem (Utah) | 2,040.54 mi (3,283.94 km) |
| Key West to Orinda (California) | 2,534.78 mi (4,079.33 km) |
| Key West to Orland Park (Illinois) | 1,228.26 mi (1,976.70 km) |
| Key West to Orlando (Florida) | 271.74 mi (437.32 km) |
| Key West to Ormond Beach (Florida) | 329.75 mi (530.68 km) |
| Key West to Oro Valley (Arizona) | 1,847.57 mi (2,973.37 km) |
| Key West to Oroville (California) | 2,522.88 mi (4,060.19 km) |
| Key West to Oshkosh (Wisconsin) | 1,397.85 mi (2,249.63 km) |
| Key West to Oskaloosa (Iowa) | 1,313.77 mi (2,114.30 km) |
