| Key West to San Luis Obispo (California) | 2,426.19 mi (3,904.58 km) |
| Key West to San Marcos (California) | 2,210.91 mi (3,558.11 km) |
| Key West to San Marcos (Texas) | 1,057.15 mi (1,701.31 km) |
| Key West to San Marino (California) | 2,272.44 mi (3,657.14 km) |
| Key West to San Mateo (California) | 2,538.37 mi (4,085.12 km) |
| Key West to San Pablo (California) | 2,544.50 mi (4,094.97 km) |
| Key West to San Rafael (California) | 2,554.45 mi (4,110.99 km) |
| Key West to San Ramon (California) | 2,520.38 mi (4,056.17 km) |
| Key West to San Tan Valley (Arizona) | 1,890.23 mi (3,042.03 km) |
| Key West to Sand Springs (Oklahoma) | 1,168.45 mi (1,880.45 km) |
| Key West to Sandusky (Ohio) | 1,167.68 mi (1,879.21 km) |
| Key West to Sandy (Oregon) | 2,666.13 mi (4,290.72 km) |
| Key West to Sandy (Utah) | 2,055.27 mi (3,307.63 km) |
| Key West to Sandy Springs (Georgia) | 666.09 mi (1,071.96 km) |
| Key West to Sanford (Florida) | 293.55 mi (472.42 km) |
