| Key West to Sanford (Maine) | 1,444.88 mi (2,325.31 km) |
| Key West to Sanford (North Carolina) | 770.50 mi (1,239.99 km) |
| Key West to Sanger (California) | 2,379.09 mi (3,828.77 km) |
| Key West to Santa Ana (California) | 2,256.10 mi (3,630.84 km) |
| Key West to Santa Barbara (California) | 2,366.04 mi (3,807.77 km) |
| Key West to Santa Clara (California) | 2,517.73 mi (4,051.90 km) |
| Key West to Santa Clara (Oregon) | 2,679.80 mi (4,312.72 km) |
| Key West to Santa Clarita (California) | 2,296.69 mi (3,696.17 km) |
| Key West to Santa Cruz (California) | 2,517.40 mi (4,051.36 km) |
| Key West to Santa Fe (New Mexico) | 1,630.83 mi (2,624.57 km) |
| Key West to Santa Fe (Texas) | 884.75 mi (1,423.86 km) |
| Key West to Santa Fe Springs (California) | 2,267.98 mi (3,649.96 km) |
| Key West to Santa Maria (California) | 2,410.80 mi (3,879.81 km) |
| Key West to Santa Monica (California) | 2,292.53 mi (3,689.46 km) |
| Key West to Santa Paula (California) | 2,328.38 mi (3,747.16 km) |
