| Key West to Santa Rosa (California) | 2,569.51 mi (4,135.22 km) |
| Key West to Santaquin (Utah) | 2,036.43 mi (3,277.32 km) |
| Key West to Santee (California) | 2,197.97 mi (3,537.30 km) |
| Key West to Sapulpa (Oklahoma) | 1,161.75 mi (1,869.65 km) |
| Key West to Saraland (Alabama) | 581.20 mi (935.34 km) |
| Key West to Sarasota (Florida) | 197.51 mi (317.86 km) |
| Key West to Sarasota Springs (Florida) | 194.51 mi (313.03 km) |
| Key West to Saratoga (California) | 2,519.89 mi (4,055.37 km) |
| Key West to Saratoga Springs (New York) | 1,356.80 mi (2,183.55 km) |
| Key West to Saratoga Springs (Utah) | 2,052.29 mi (3,302.84 km) |
| Key West to Sartell (Minnesota) | 1,611.38 mi (2,593.26 km) |
| Key West to Satellite Beach (Florida) | 260.09 mi (418.57 km) |
| Key West to Sauk Rapids (Minnesota) | 1,608.54 mi (2,588.69 km) |
| Key West to Sault Ste. Marie (Michigan) | 1,521.15 mi (2,448.05 km) |
| Key West to Savage (Minnesota) | 1,538.87 mi (2,476.58 km) |
