| Key West to Scottsboro (Alabama) | 741.97 mi (1,194.09 km) |
| Key West to Scottsdale (Arizona) | 1,913.98 mi (3,080.25 km) |
| Key West to Scranton (Pennsylvania) | 1,215.42 mi (1,956.03 km) |
| Key West to Seabrook (Maryland) | 1,036.78 mi (1,668.54 km) |
| Key West to Seabrook (Texas) | 884.67 mi (1,423.74 km) |
| Key West to Seaford (New York) | 1,211.18 mi (1,949.20 km) |
| Key West to Seagoville (Texas) | 1,054.16 mi (1,696.51 km) |
| Key West to Seal Beach (California) | 2,267.05 mi (3,648.47 km) |
| Key West to Searcy (Arkansas) | 947.47 mi (1,524.81 km) |
| Key West to Seaside (California) | 2,502.16 mi (4,026.84 km) |
| Key West to SeaTac (Washington) | 2,715.62 mi (4,370.37 km) |
| Key West to Seattle (Washington) | 2,721.16 mi (4,379.28 km) |
| Key West to Sebastian (Florida) | 236.41 mi (380.46 km) |
| Key West to Sebring (Florida) | 202.26 mi (325.51 km) |
| Key West to Secaucus (New Jersey) | 1,205.62 mi (1,940.26 km) |
