| Key West to Security-Widefield (Colorado) | 1,659.37 mi (2,670.49 km) |
| Key West to Sedalia (Missouri) | 1,184.72 mi (1,906.62 km) |
| Key West to Sedro-Woolley (Washington) | 2,740.08 mi (4,409.73 km) |
| Key West to Seguin (Texas) | 1,053.61 mi (1,695.62 km) |
| Key West to Selden (New York) | 1,234.11 mi (1,986.11 km) |
| Key West to Selma (Alabama) | 629.22 mi (1,012.63 km) |
| Key West to Selma (California) | 2,380.71 mi (3,831.38 km) |
| Key West to Selma (Texas) | 1,073.61 mi (1,727.80 km) |
| Key West to Seminole (Florida) | 235.01 mi (378.21 km) |
| Key West to Seven Hills (Ohio) | 1,161.90 mi (1,869.89 km) |
| Key West to Seven Oaks (South Carolina) | 656.34 mi (1,056.28 km) |
| Key West to Severn (Maryland) | 1,049.53 mi (1,689.05 km) |
| Key West to Severna Park (Maryland) | 1,048.46 mi (1,687.34 km) |
| Key West to Sevierville (Tennessee) | 789.56 mi (1,270.68 km) |
| Key West to Seymour (Indiana) | 1,022.43 mi (1,645.45 km) |
