| Key West to St. Simons (Georgia) | 457.56 mi (736.37 km) |
| Key West to Stafford (Texas) | 916.56 mi (1,475.05 km) |
| Key West to Stallings (North Carolina) | 731.62 mi (1,177.42 km) |
| Key West to Stamford (Connecticut) | 1,236.91 mi (1,990.61 km) |
| Key West to Stanford (California) | 2,529.19 mi (4,070.34 km) |
| Key West to Stanton (California) | 2,262.97 mi (3,641.90 km) |
| Key West to Star (Idaho) | 2,358.65 mi (3,795.87 km) |
| Key West to Starkville (Mississippi) | 747.44 mi (1,202.89 km) |
| Key West to State College (Pennsylvania) | 1,143.77 mi (1,840.71 km) |
| Key West to Staten Island (New York) | 1,191.36 mi (1,917.31 km) |
| Key West to Statesboro (Georgia) | 543.99 mi (875.47 km) |
| Key West to Statesville (North Carolina) | 777.10 mi (1,250.62 km) |
| Key West to Staunton (Virginia) | 952.77 mi (1,533.33 km) |
| Key West to Steamboat Springs (Colorado) | 1,815.96 mi (2,922.51 km) |
| Key West to Steiner Ranch (Texas) | 1,065.00 mi (1,713.96 km) |
