| Key West to Storm Lake (Iowa) | 1,464.31 mi (2,356.58 km) |
| Key West to Storrs (Connecticut) | 1,310.54 mi (2,109.11 km) |
| Key West to Stoughton (Wisconsin) | 1,337.29 mi (2,152.16 km) |
| Key West to Stow (Ohio) | 1,147.97 mi (1,847.48 km) |
| Key West to Streamwood (Illinois) | 1,260.53 mi (2,028.63 km) |
| Key West to Streator (Illinois) | 1,214.12 mi (1,953.94 km) |
| Key West to Streetsboro (Ohio) | 1,152.43 mi (1,854.65 km) |
| Key West to Strongsville (Ohio) | 1,157.22 mi (1,862.37 km) |
| Key West to Stuart (Florida) | 205.29 mi (330.38 km) |
| Key West to Stuarts Draft (Virginia) | 943.48 mi (1,518.38 km) |
| Key West to Sturgis (Michigan) | 1,208.97 mi (1,945.64 km) |
| Key West to Suamico (Wisconsin) | 1,431.06 mi (2,303.07 km) |
| Key West to Sudley (Virginia) | 1,014.14 mi (1,632.10 km) |
| Key West to Suffern (New York) | 1,225.07 mi (1,971.57 km) |
| Key West to Suffolk (Virginia) | 891.69 mi (1,435.04 km) |
