| Keystone to Southern Pines (North Carolina) | 522.76 mi (841.30 km) |
| Keystone to Southfield (Michigan) | 991.85 mi (1,596.24 km) |
| Keystone to Southgate (Michigan) | 972.98 mi (1,565.86 km) |
| Keystone to Southlake (Texas) | 926.71 mi (1,491.40 km) |
| Keystone to Spanaway (Washington) | 2,504.64 mi (4,030.82 km) |
| Keystone to Spanish Fork (Utah) | 1,844.29 mi (2,968.10 km) |
| Keystone to Spanish Lake (Missouri) | 856.24 mi (1,377.98 km) |
| Keystone to Spanish Springs (Nevada) | 2,251.17 mi (3,622.90 km) |
| Keystone to Sparks (Nevada) | 2,252.71 mi (3,625.38 km) |
| Keystone to Spartanburg (South Carolina) | 472.40 mi (760.26 km) |
| Keystone to Spearfish (South Dakota) | 1,625.52 mi (2,616.02 km) |
| Keystone to Speedway (Indiana) | 832.26 mi (1,339.40 km) |
| Keystone to Spencer (Iowa) | 1,251.13 mi (2,013.49 km) |
| Keystone to Spokane (Washington) | 2,299.28 mi (3,700.33 km) |
| Keystone to Spokane Valley (Washington) | 2,290.68 mi (3,686.50 km) |
