| Knoxville to Sacile | 4,764.43 mi (7,667.61 km) |
| Knoxville to Sala Consilina | 5,101.43 mi (8,209.96 km) |
| Knoxville to Salemi | 5,074.36 mi (8,166.40 km) |
| Knoxville to Salerno | 5,053.94 mi (8,133.54 km) |
| Knoxville to Salo | 4,695.02 mi (7,555.90 km) |
| Knoxville to Salsomaggiore Terme | 4,698.23 mi (7,561.07 km) |
| Knoxville to Saluzzo | 4,596.78 mi (7,397.80 km) |
| Knoxville to Salzano | 4,763.68 mi (7,666.40 km) |
| Knoxville to Samarate | 4,620.46 mi (7,435.91 km) |
| Knoxville to San Benedetto del Tronto | 4,931.16 mi (7,935.93 km) |
| Knoxville to San Biagio di Callalta | 4,769.34 mi (7,675.51 km) |
| Knoxville to San Bonifacio | 4,733.41 mi (7,617.69 km) |
| Knoxville to San Casciano in Val di Pesa | 4,789.93 mi (7,708.64 km) |
| Knoxville to San Cataldo | 5,141.10 mi (8,273.80 km) |
| Knoxville to San Cesareo | 4,925.89 mi (7,927.46 km) |
