| Laguna Niguel to Denver (Colorado) | 830.24 mi (1,336.14 km) |
| Laguna Niguel to Portland (Oregon) | 870.16 mi (1,400.40 km) |
| Laguna Niguel to Seattle (Washington) | 1,003.02 mi (1,614.20 km) |
| Laguna Niguel to Dallas (Texas) | 1,210.10 mi (1,947.47 km) |
| Laguna Niguel to Houston (Texas) | 1,334.95 mi (2,148.40 km) |
| Laguna Niguel to Minneapolis (Minnesota) | 1,518.75 mi (2,444.20 km) |
| Laguna Niguel to St. Louis (Missouri) | 1,567.13 mi (2,522.05 km) |
| Laguna Niguel to Chicago (Illinois) | 1,728.42 mi (2,781.62 km) |
| Laguna Niguel to Atlanta (Georgia) | 1,906.03 mi (3,067.45 km) |
| Laguna Niguel to Detroit (Michigan) | 1,966.33 mi (3,164.50 km) |
| Laguna Niguel to Tampa (Florida) | 2,117.71 mi (3,408.12 km) |
| Laguna Niguel to Washington (District of Columbia) | 2,279.28 mi (3,668.15 km) |
| Laguna Niguel to Baltimore (Maryland) | 2,299.22 mi (3,700.23 km) |
| Laguna Niguel to Miami (Florida) | 2,300.81 mi (3,702.79 km) |
| Laguna Niguel to Philadelphia (Pennsylvania) | 2,375.35 mi (3,822.75 km) |
| Laguna Niguel to Brooklyn (New York) | 2,435.51 mi (3,919.58 km) |
| Laguna Niguel to New York (New York) | 2,436.66 mi (3,921.43 km) |
| Laguna Niguel to Queens (New York) | 2,443.15 mi (3,931.87 km) |
| Laguna Niguel to Los Angeles (California) | 57.14 mi (91.97 km) |
| Laguna Niguel to San Diego (California) | 58.73 mi (94.52 km) |
| Laguna Niguel to Las Vegas (Nevada) | 232.51 mi (374.19 km) |
| Laguna Niguel to Boston (Massachusetts) | 2,578.83 mi (4,150.22 km) |
| Laguna Niguel to Riverside (California) | 33.50 mi (53.92 km) |
| Laguna Niguel to Phoenix (Arizona) | 323.35 mi (520.38 km) |
| Laguna Niguel to San Francisco (California) | 395.08 mi (635.82 km) |
