| Laguna Niguel to Sacile | 6,127.10 mi (9,860.62 km) |
| Laguna Niguel to Sala Consilina | 6,525.27 mi (10,501.41 km) |
| Laguna Niguel to Salemi | 6,571.48 mi (10,575.78 km) |
| Laguna Niguel to Salerno | 6,482.93 mi (10,433.26 km) |
| Laguna Niguel to Salo | 6,085.22 mi (9,793.22 km) |
| Laguna Niguel to Salsomaggiore Terme | 6,108.37 mi (9,830.47 km) |
| Laguna Niguel to Saluzzo | 6,035.07 mi (9,712.50 km) |
| Laguna Niguel to Salzano | 6,138.35 mi (9,878.71 km) |
| Laguna Niguel to Samarate | 6,028.27 mi (9,701.56 km) |
| Laguna Niguel to San Benedetto del Tronto | 6,331.92 mi (10,190.24 km) |
| Laguna Niguel to San Biagio di Callalta | 6,138.38 mi (9,878.76 km) |
| Laguna Niguel to San Bonifacio | 6,119.37 mi (9,848.18 km) |
| Laguna Niguel to San Casciano in Val di Pesa | 6,207.94 mi (9,990.71 km) |
| Laguna Niguel to San Cataldo | 6,630.21 mi (10,670.29 km) |
| Laguna Niguel to San Cesareo | 6,358.02 mi (10,232.24 km) |
