| Laguna Niguel to Savignano sul Rubicone | 6,223.82 mi (10,016.27 km) |
| Laguna Niguel to Savona | 6,085.29 mi (9,793.33 km) |
| Laguna Niguel to Scafati | 6,471.38 mi (10,414.68 km) |
| Laguna Niguel to Scalea | 6,563.70 mi (10,563.26 km) |
| Laguna Niguel to Scandiano | 6,142.80 mi (9,885.87 km) |
| Laguna Niguel to Scandicci | 6,202.93 mi (9,982.65 km) |
| Laguna Niguel to Schio | 6,105.26 mi (9,825.47 km) |
| Laguna Niguel to Sciacca | 6,597.93 mi (10,618.34 km) |
| Laguna Niguel to Scicli | 6,692.28 mi (10,770.19 km) |
| Laguna Niguel to Scordia | 6,669.72 mi (10,733.87 km) |
| Laguna Niguel to Scorze | 6,136.06 mi (9,875.03 km) |
| Laguna Niguel to Sedico | 6,106.88 mi (9,828.07 km) |
| Laguna Niguel to Sedriano | 6,041.06 mi (9,722.14 km) |
| Laguna Niguel to Segni | 6,372.22 mi (10,255.10 km) |
| Laguna Niguel to Segrate | 6,051.34 mi (9,738.70 km) |
