| Laguna Niguel to Selargius | 6,367.98 mi (10,248.27 km) |
| Laguna Niguel to Selvazzano Dentro | 6,135.92 mi (9,874.81 km) |
| Laguna Niguel to Senago | 6,041.31 mi (9,722.55 km) |
| Laguna Niguel to Senigallia | 6,269.89 mi (10,090.41 km) |
| Laguna Niguel to Seravezza | 6,158.98 mi (9,911.92 km) |
| Laguna Niguel to Seregno | 6,040.03 mi (9,720.49 km) |
| Laguna Niguel to Seriate | 6,054.86 mi (9,744.36 km) |
| Laguna Niguel to Sermoneta | 6,378.27 mi (10,264.83 km) |
| Laguna Niguel to Serramanna | 6,350.76 mi (10,220.56 km) |
| Laguna Niguel to Serravalle Pistoiese | 6,183.74 mi (9,951.77 km) |
| Laguna Niguel to Sessa Aurunca | 6,426.23 mi (10,342.01 km) |
| Laguna Niguel to Sesto Calende | 6,017.44 mi (9,684.13 km) |
| Laguna Niguel to Sesto Fiorentino | 6,199.12 mi (9,976.53 km) |
| Laguna Niguel to Sesto San Giovanni | 6,047.11 mi (9,731.89 km) |
| Laguna Niguel to Sestri Levante | 6,117.26 mi (9,844.78 km) |
